Includes bibliographical references and index.
|Statement||Agoston Meszaros and Gusztav Balogh editors|
|Series||Pharmacology--research, safety testing and regulation series, Pharmacology-research, safety testing, and regulation series|
|LC Classifications||QR177 .M865 2010|
|The Physical Object|
|Pagination||xiv, 271 p. :|
|Number of Pages||271|
|LC Control Number||2009041932|
This book is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry. First, these bacteria may accumulate multiple genes, each coding for resistance to a single drug, within a single cell. This accumulation occurs typically on resistance (R) plasmids. Second, multidrug resistance may also occur by the increased expression of genes that code for multidrug efflux pumps, extruding a wide range of by: The resistance among various microbial species (infectious agents) to different antimicrobial drugs has emerged as a cause of public health threat all over the world at a terrifying rate. Due to the pacing advent of new resistance mechanisms and decrease in efficiency of treating common infectious diseases, it results in failure of microbial response to standard treatment, leading to prolonged Cited by: Meenakshi R. Ramanathan, James M. Sanders, in Side Effects of Drugs Annual, Abstract. Multidrug resistance continues to be a problem in the treatment of tuberculosis (TB). With more cases of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB), clinicians are reverting to second-line and third-line agents, which have proven to be more toxic in nature and costly.
an t imicrob ial drug resistance which is an exp andin g pr oblem in medical wor ld. MDR can be classi ed (Figure)a sp r i m a r y or se condary resistance. As early as , he wrote a book entitled Infectious Multiple Drug Resistance and noted that while “we owe to chemotherapy [antibiotics] the debt of reducing the high mortality rate of many bacterial infections [and to hygiene and vaccines the debt of preventing them], in helping to solve some of the problems of infectious diseases Cited by: The ATP-binding cassette transporters (ABC transporters) are a transport system superfamily that is one of the largest and possibly one of the oldest gene is represented in all extant phyla, from prokaryotes to humans.. ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated AAA ro: IPR multiple drug resistance: [ re-zis´tans ] 1. opposition, or counteracting force, as opposition of a conductor to passage of electricity or other energy or substance. 2. the natural ability of a normal organism to remain unaffected by noxious agents in its environment; see also immunity. 3. in psychology or psychiatry, conscious or unconscious.
Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by. ISBN: OCLC Number: Description: 1 online resource (xiv, pages): illustrations (some color). Contents: Profile of genetic and cellular multiple drug resistance in a diagnostic and therapeutic strategy in acute leukemia in children and adults / Jan Styczynski, Joanna Szczepanek --Herb-drug interactions and implication in drug monitoring / Ping Li, Shu. Antibiotic resistance is one of the biggest public health challenges of our time. Each year in the U.S., at least million people get an antibiotic-resistant infection, and more t people die. Fighting this threat is a public health priority that requires a collaborative global approach across sectors. 4 INFECTIOUS MULTIPLE DRUG RESISTANCE S. Falkow, Department of Microbiology, University of Washington, Seattle This volume is a documented guide to the study of infectious-multiple-drug resistance (R) factors and other bacterial plasmids. The first three chapters review the properties of the classical F-factor and the bacteriophage X so that Cited by: